home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410p.zip
/
M94A3121.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
3KB
|
45 lines
Document 3121
DOCN M94A3121
TI HIV-1 infection and liver disease in IDUs.
DT 9412
AU Miguez-Burbano MJ; Lu Y; Page B; Gregory M; Fletcher MA; Quesada J;
Shor-Posner G; Baum MK; Dept of Epidemiology, University of Miami School
of Medicine, FL.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):149 (abstract no. PB0021). Unique
Identifier : AIDSLINE ICA10/94369454
AB OBJECTIVE: As liver disease is frequently observed in intravenous drug
users (IDUs), the clinical significance of liver dysfunction in HIV
disease, and its relationship to immune activation, serum protein and
lipid profiles, was determined in HIV-1 seropositive and seronegative
IDUs. METHODS: Liver function tests (GGT, GOT), immune activation (beta
2-microglobulin, B2M), serum protein (total protein, albumin and
globulin) and lipid profiles (serum choelesterol, triglycerides), were
evaluated in 30 HIV+, asymptomatic IDUs (mean CD4 440 +/- 283) and 40
seronegative IDUs (mean CD4 961 +/- 353). RESULTS: Elevated liver
enzymes were observed in 35% of the HIV- and 50% of the HIV+ subjects.
Levels of GOT were significantly higher in the seropositives (67.3 +/-
55.3) relative to the seronegatives (p < 0.05). The HIV-1+ IDUs also
exhibited increased immune activation (B2M 4.31 +/- 1.6) as well as
levels of serum triglycerides (153.7 +/- 37) and globulins (4.45 +/-
1.0); hypocholesterolemia (< 150 mg/dl) was observed in 40% of the HIV
seropositives and 28% of the seronegatives. Abnormal liver function in
HIV+ patients was associated with significantly higher levels of
triglycerides (185.9 +/- 106.6 vs 111.6 +/- 58.9, p = 0.05) and
cholesterol (174.2 +/- 39.2 vs 133 +/- 40.9 p < 0.02), as compared to
HIV+ IDUs with normal liver enzymes; proteins and B2M were similar in
the groups with and without abnormal liver function. DISCUSSION AND
CONCLUSIONS: Liver dysfunction in IDUs may intensify the impact of HIV
infection on lipid status, but does not appear to affect the level of
serum proteins or immune activation.
DE beta 2-Microglobulin/ANALYSIS Acquired Immunodeficiency
Syndrome/*PHYSIOPATHOLOGY Aspartate Aminotransferase/BLOOD Blood
Proteins/ANALYSIS Cholesterol/BLOOD Comparative Study
Gamma-Glutamyltransferase/BLOOD Human HIV Seronegativity/*PHYSIOLOGY
HIV Seropositivity/*PHYSIOPATHOLOGY HIV-1/*ISOLATION & PURIF *Liver
Function Tests *Substance Abuse, Intravenous Triglycerides/BLOOD
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).